LDN: new promising support treatment to CURE CFS??

[Sushi]

Here is a fascinating recording of an interview with one of the primary researchers in LDN--Dr. Ian Zagon.

http://www.blogtalkradio.com/Mary-Boyle ... adley-Show

Susan

[serg1942]

Hola Susan,

Thank you so much for posting this recording. I have tried to understand it, and I estimate I have caught a 20% of the talk, but think I know the main subjects they have talked about, although I have a few doubts? Would you mind to help me in understanding them? (Sushi or whoever who have heard it who understand english here! ha!)

Look, these are the things I have not understood completely:

1- Dr. Ian Zago says LDN can be inactivated by (WHAT???), so it can’t work…

2- Sometimes, it seems that LDN stops working, and then, does more effect taken every other day or even every three days, and that they are working on figuring out what’s the better dosage is…Is that correct?

3- Talking about pancreatic cancer, I am not sure whether Dr. Zagon says LDN works better together with chemotherapy, or alone…

4- I think he says you actually can take LDN anytime of the day. Not necessary at night, if it disturbs the sleep…have I understood fine? He says something like it is a legend the fact that LDN works better at night…but not sure!

5- Finally he says at the end of the talk that hypothyroidism can improve with LDN, but that there’s no scientific evidence for that…is this right?

Thank you so much in advance Susan! He talked very fast!! I did understand better the women…

Un abrazo,
Sergio

[Sushi]

Sergio and others,

Here is a link to a summary of Dr. Ian Zagon's interview--he approved it.

http://www.ldnnow.co.uk/8601.html?entry ... cbc9109c46

Sushi

[Sushi]

Hi all,

There has been controversy about whether it is better to take LDN at bedtime, or whether the same efficacy is found if you take it during the day.

In the interview by Dr. Zagon, referenced in the previous few posts, Dr Zagon says that there is no difference in effect whenever you take LDN, and that the reason he had suggested taking it at night was that for a few hours after taking LDN your opioid receptors are blocked and this can be uncomfortable for some--hence you might wish to sleep through it.

He also said that a sort of urban legend had started from his comment on dosing time, but that there was no relation between LDN's efficacy and the circadian rhythm.

I have just been reading commentary by one of the other primary clinicians using LDN, Dr Bernard Bihari. Apparently he has had more clinical experience using LDN in humans. He disagrees with Dr. Zagon's statement that there is no difference in efficacy according to dosing time. He believes that the circadian rhythm is a factor because the body produces most of its endorphins between approx 2 and 4 a.m.

To summarize from another board: When LDN is taken late at night (between 9 p.m.-- 3 a.m.) it causes a marked increase in the production of beta-endorphin and metenkephalin. This happens in the very early morning hours when it is believed that most of these hormones are produced by the body. Studies have demonstrated that LDN can induce as much as a three-fold increase in their production overnight. http://ldn.proboards.com/index.cgi?boar ... hread=1297

So, if you are trying LDN, you might wish to experiment yourself with dosing time as this controversy remains.

Susan

[Sushi]

Personal update on LDN: I am raising my dose slowly to avoid any abrupt changes. I began at 1.5 mg about 5 weeks ago and am now taking 3 mg. Each time I raise the dose there are a couple of days of slightly disturbed sleep, and then after that I sleep much better than I did previously.

Also each time I raise my dose, I feel better and have more "good" days with less brain fog. This medication is thought to modulate immune response, and so far I'd guess my immune response has increased as a couple of old infections have emerged, and have been successfully targeted. Also, and very important for those of us on a methylation protocol, I am noticing that I am handling detox much better! This great as I have stumbled a lot with detox issues.

I feel generally very encouraged by this therapy. I am shooting for the target dose of 4.5 mg, which many have experienced as the most efficacious.

Susan

[Janis]

Susan and others on LDN

I'm doing great on 3.0 mg now, but wondering about taking charcoal. I used to take charcoal at bedtime, but now that I'm taking the LDN, I'm not taking any charcoal. What are you doing to get around this? (if you have CBS+ and need to stay with the ammonia program?)

Janis

[serg1942]

Hola Janis,

I do take over 6-9 caps of charcoal daily...I solve the problem you bring up taking 2-3 caps in the middle of the night, where I use to wake up to go to the toilette...I think many Drs recommend to take charcoal at this time, as the body detoxifies at nights, although is something I don't understand, as I thought charcoal is suppose to absorb the toxins released with bile, and I think bile is released before meals...Maybe the body release bile also through the night too??? don't know..

Regards,
Sergio

[Janis]

That's a great idea. I usually wake up once. I will leave a glass of charcoal by my bedside (I use the powder because it's cheaper and swallow it in gulps.)

Hope you are doing better, Sergio.
Janis

[roseadison]

I had taken LDN and I had a deep sleep after it. But then after my friend says that it will be harmfull so I stop taking it. Is it true that it is harmfull ??

[Janis]

Rose Adison
Go to http://www.lowdosenaltrexone.org and read for yourself. I don't know where your friend got the idea it is harmful. IT seems to be a very safe drug and those who tolerate it (e.g. can sleep) seem to get benefits.
Jans